Table 2.
Overview of PIANOFORTE ongoing research projects [4]
| Topics of PIANOFORTE Open Call | Selected Projects |
|---|---|
| Topic 1 (2023, 2024): Developing a knowledge base for a better understanding of disease pathogenesis of ionising radiation-induced cancer to improve risk assessment. |
From the 2023 open call • DISCOVER – Dissecting radIation effectS into the Cerebellum micrOenVironmEnt driving tumour pRomotion (from call 2023) |
| From the 2024 open call • CORNET – deCiphering the rOle of micRoenvironment after low-dose exposure for coloN carcinogenEsis and radiaTion risk • MIRAMARE – Mechanisms of the inversed relationship between menarche age and radiation-induced breast and endometrial cancer • UBT-Rad – Unraveling brain tumor formation after low dose irradiation exposure |
|
| Topic 2 (2023): Individualised diagnostic as well as therapeutic procedures with regard to optimisation of the benefit/risk ratio. |
• IMAGEOMICS – Optimizing Benefit/Risk Ratio in Breast Cancer Diagnosis and Radiotherapy: Identifying Molecular, Cellular and Imaging Signatures of Breast Cancer Heterogeneity to Improve Personalised Therapeutic Strategies for Synergistic Treatment Combinations • IMMPRINT – Integrated molecular Imaging for Personalized Biomarker-based Breast Cancer Characterization and Treatment • LUTADOSE – Personalized dosimetry to improve the clinical outcome of prostate cancer patients treated with 177Lu/225Ac-PSMA targeted therapies • SONORA – Towards safe, optimized and personalized radiology and radiotherapy procedures for pregnant patients • VERIFIED – In vivo patient-specific real-time dosimetry for adaptive radiotherapy |
| Topic 3 (2023): Development of risk assessment and risk management approaches and technological capabilities to cope with scenarios arising from threats due to war or armed conflicts situations or natural disasters taking into consideration social, ethical and legal issues. |
• CITISTRA – Citizen measurements as complementary radiation monitoring strategy in threats due to armed conflict or natural disasters • PREDICT – ImPRovements in atmospheric dispErsion moDellIng and proteCTive action strategies in case of nuclear detonations • RRADEW – Resilience to RADiological Events in Wartime |
| Topic 2 (2024): Ensure readiness and scientific knowledge to support Environmental Impact Assessment and Emergency Preparedness and Response for novel nuclear technologies | • CATAPULT – Comprehensive Assessment and Preparedness for Emerging Nuclear Technologies • GIROSCOPE – Guidance for Innovative Reactor Off-Site Consequences, Planned and Emergency |
| Topic 4 (2024): Implementation of new and optimised radiation therapy approaches for better targeting to protect healthy tissues better against detrimental effects of ionising radiation | • DOSELIA – Computing whole-body radiation dose distributions and subsequent cancer risks from modern radiotherapy techniques in paediatric patients • EMPATHY – Evaluation and optimization of proton arc therapy • KAYAC+ – Knowledge on outcome of adolescent and young adults with cancer |
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